rs6814514

This is a intron variant variant in the GPM6A gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)

Allele G

OR 0.01

p 2.0e-13

N 3,382,012

Large GWAS

European, East Asian, Hispanic or Latin American, African unspecified

About GPM6A

Predicted to enable calcium channel activity. Involved in neuron migration and stem cell differentiation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

View all GPM6A variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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