rs6832151

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Graves disease

Chu X et al. “A genome-wide association study identifies two new risk loci for Graves' disease.” Nature Genetics 43(9):897-901 (2011)
Allele G
OR 1.24
p 1.0e-13
N 2,958
Large GWAS
East Asian
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Research that mentions this SNP (1)

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Identification of BACH2 as a susceptibility gene for Graves’ disease in the Chinese Han population based on a three-stage genome-wide association study
AssociationN=19,042Wei Liu et al.(2014)· Human Genetics

Three-stage genome-wide association study in 9,285 Chinese Han GD patients and 9,757 controls identifying BACH2 as a susceptibility gene for Graves' disease. rs2474619 in BACH2 intron 2 showed the strongest association with GD (OR=1.13, P=3.28×10⁻⁸). Fine mapping analysis also identified rs9344996 as an independent variant (OR=1.10, P=2.06×10⁻⁵), though rs2474619 remained the primary disease-associated signal.

Traits studied:Autoimmune thyroid diseaseCeliac diseaseCrohn's diseaseGraves' diseaseHashimoto's thyroiditisMultiple sclerosisType 1 diabetesVitiligo
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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