rs6843082

This is a coding sequence variant variant.

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

atrial fibrillation

Roselli C et al. “Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.” Nature Genetics 57(3):539-547 (2025)
Allele G
OR 1.45
p —
N 1,650,345
Meta-analysisLarge GWAS
multi-ancestry
Yuan S et al. “Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation.” Nature Communications 16(1):6426 (2025)
Allele G
OR 0.34
p 5.0e-305
N 1,840,341
Large GWAS
European
Roselli C et al. “Multi-ethnic genome-wide association study for atrial fibrillation.” Nature Genetics 50(9):1225-1233 (2018)
Allele G
OR 1.47
p —
N 588,190
Large GWAS
multi-ancestry
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.20
p 3.0e-33
N 118,847
Major Consortium StudyLarge GWAS
African American or Afro-Caribbean
Low SK et al. “Identification of six new genetic loci associated with atrial fibrillation in the Japanese population.” Nature Genetics 49(6):953-958 (2017)
Allele G
OR 1.84
p 1.0e-126
N 36,792
Large GWAS
multi-ancestry
Ellinor PT et al. “Common variants in KCNN3 are associated with lone atrial fibrillation.” Nature Genetics 42(3):240-4 (2010)
Allele G
OR 2.03
p 3.0e-28
N 14,179
Large GWAS
European
Christophersen IE et al. “Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation.” Nature Genetics 49(6):946-952 (2017)
Allele G
OR 1.40
p 4.0e-8
N 5,875
Large GWAS
African American or Afro-Caribbean

cardiac arrhythmia

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.13
p 3.0e-130
N 557,567
Major Consortium StudyLarge GWAS
multi-ancestry

prothrombin time measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.06
p 1.0e-54
N 240,535
Major Consortium StudyLarge GWAS
multi-ancestry

heart rate

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.03
p 7.0e-21
N 425,748
Major Consortium StudyLarge GWAS
European

stroke

Traylor M et al. “Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.” The Lancet. Neurology 11(11):951-62 (2012)
Allele G
OR 1.36
p 3.0e-16
N 74,393
Meta-analysisLarge GWAS
multi-ancestry

encounter with health service

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.22
p 9.0e-14
N 59,085
Major Consortium StudyLarge GWAS
Hispanic or Latin American

blood coagulation disease

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.17
p 1.0e-13
N 623,334
Major Consortium StudyLarge GWAS
multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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