rs6882649

This is a intron variant variant in the NREP gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

breast carcinoma

Shu X et al. “Identification of novel breast cancer susceptibility loci in meta-analyses conducted among Asian and European descendants.” Nature Communications 11(1):1217 (2020)

Allele T

OR 1.04

p 6.0e-10

N 277,932

Large GWAS

multi-ancestry

Michailidou K et al. “Association analysis identifies 65 new breast cancer risk loci.” Nature 551(7678):92-94 (2017)

Allele T

OR 1.03

p 4.0e-9

N 139,274

Large GWAS

multi-ancestry

About NREP

Predicted to be involved in axon regeneration; regulation of neuron differentiation; and regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

View all NREP variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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