rs6902875
This is a downstream gene variant variant in the MOXD1 gene.
▶Research that mentions this SNP (1)
▶Common Genetic Variants on 6q24 Associated With Exceptional Episodic Memory Performance in the ElderlyAssociationN=4,473Sandra Barral et al.(2014)· JAMA Neurology
This study identified common genetic variants on chromosome 6q24 associated with exceptional episodic memory (EEM) performance in elderly individuals through genome-wide linkage analysis in 467 Long Life Family Study participants, followed by replication in 4,006 nondemented elderly individuals. Meta-analysis of four independent cohorts identified SNPs rs9321334 (P=0.009) and rs6902875 (P=0.013) as nominally significantly associated with episodic memory; in individuals lacking APOE ε4 alleles, rs6902875 achieved experiment-wise significance (P=6.7×10−5). A three-SNP haplotype (A-A-C) including rs9321334, rs6902875, and rs4897574 showed strong association (P=2.4×10−5), with the MOXD1 gene as a plausible candidate involved in norepinephrine biosynthesis.
About MOXD1
Predicted to enable copper ion binding activity and dopamine beta-monooxygenase activity. Predicted to be involved in dopamine catabolic process; norepinephrine biosynthetic process; and octopamine biosynthetic process. Part of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all MOXD1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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