rs6903608

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Hodgkins lymphoma

Enciso-Mora V et al. “A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).” Nature Genetics 42(12):1126-1130 (2010)
Allele G
OR 1.70
p 3.0e-50
N 5,788
Large GWAS
European
Cozen W et al. “A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.” Nature Communications 5:3856 (2014)
Allele G
OR 1.64
p 7.0e-31
N 9,693
Meta-analysis
European
Frampton M et al. “Variation at 3p24.1 and 6q23.3 influences the risk of Hodgkin's lymphoma.” Nature Communications 4:2549 (2013)
Allele G
OR 1.62
p 5.0e-27
N 7,882
Large GWAS
European
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Research that mentions this SNP (1)

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Modeling HLA associations with EBV‐positive and ‐negative Hodgkin lymphoma suggests distinct mechanisms in disease pathogenesis
AssociationN=850Johnson PC et al.(2015)· International Journal of Cancer

This case-control study of 503 classical Hodgkin lymphoma (cHL) patients and 347 controls identified distinct HLA associations stratified by EBV status. For EBV-positive cHL, HLA-A*01:01 (OR=2.49) and HLA-B*37:01 (OR=2.58) were associated with increased risk, while HLA-DRB1*15:01 and HLA-DPB1*01:01 were protective. For EBV-negative cHL, the SNP rs6903608 C variant (OR=3.61, p=4.5×10⁻⁷) was the strongest predictor, independent of HLA alleles, suggesting distinct disease mechanisms between EBV-positive and EBV-negative subtypes.

Traits studied:Classical Hodgkin lymphomaEBV-negative Hodgkin lymphomaEBV-positive Hodgkin lymphoma
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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