rs6922617

This is a intergenic variant variant.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Alzheimer disease, p-tau measurement

Cruchaga C et al. “GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.” Neuron 78(2):256-68 (2013)
Allele A
OR —
β 0.094
p 4.0e-8
N 1,278
Large GWAS
European
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Research that mentions this SNP (1)

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Extreme cerebrospinal fluid amyloid β levels identify family with late‐onset Alzheimer's disease presenilin 1 mutation
ReviewJohn S. K. Kauwe et al.(2007)· Annals of Neurology

A review of genetic discoveries in Alzheimer's disease using cerebrospinal fluid (CSF) levels of amyloid-beta 42 (Aβ42) and phosphorylated tau (pTau181) as endophenotypes. The paper discusses multiple GWAS and sequencing studies that identified novel AD risk variants including rs9877502 (3q28, p=4.89×10⁻⁹), rs514716 in GLIS3 (p=1.07×10⁻⁸), and rs6922617 in TREM cluster (p=3.58×10⁻⁸), as well as functional characterization of known AD variants including APOE, MAPT, and TREM2. The review emphasizes the increased statistical power of using quantitative CSF biomarkers compared to traditional case-control designs.

Traits studied:AD progression rateAlzheimer's diseaseAmyloid depositionCerebrospinal fluid amyloid-beta 42 levelsCerebrospinal fluid phosphorylated tau (pTau181) levelsCerebrospinal fluid tau levelsCognitive declineTau pathology
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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