rs6922686

This is a intron variant variant in the MEP1A gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

glomerular filtration rate

Liu H et al. “Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.” Nature Genetics 54(7):950-962 (2022)

Allele A

OR 6.24

p 5.0e-10

N 1,508,659

Large GWAS

multi-ancestry

About MEP1A

Enables metallodipeptidase activity. Involved in epidermal growth factor receptor ligand maturation. Located in extracellular exosome. Part of meprin A complex. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all MEP1A variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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