rs694066
This is a regulatory region variant variant in the GAL gene.
▶Research that mentions this SNP (1)
▶Large candidate gene association study reveals genetic risk factors and therapeutic targets for fibromyalgiaAssociationN=1,844Shad B. Smith et al.(2012)· Arthritis & Rheumatism
Large candidate gene association study of fibromyalgia identifying genetic risk factors across 350 genes involved in nociception, inflammation, and mood. Discovery phase (496 FM patients, 348 controls) found significant associations for GABRB3 (rs4906902, p=3.65×10⁻⁶, OR=0.46), TAAR1 (rs8192619, p=1.11×10⁻⁵, OR=3.8), and GBP1 (rs7911, p=1.06×10⁻⁴, OR=1.7). Replication phase (1004 FM cases, 3725 controls) confirmed association for TAAR1, RGS4, CNR1, and GRIA4 genes, suggesting multiple biological pathways underlying fibromyalgia susceptibility.
About GAL
This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess antifungal activity and hypothesized to be part of the innate immune system. [provided by RefSeq, Jul 2015]
View all GAL variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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