rs6967330
This is a protein-altering variant in the CDHR3 gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
asthma exacerbation measurement
Ahluwalia TS et al. “FUT2-ABO epistasis increases the risk of early childhood asthma and Streptococcus pneumoniae respiratory illnesses.” Nature Communications 11(1):6398 (2020)
Allele A
OR 1.41
p 2.0e-23
N 68,281
Large GWAS
European
body height
Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele A
OR 0.01
p 2.0e-19
N 5,314,291
Large GWAS
European, Hispanic or Latin American, East Asian, African unspecified, South Asian
childhood onset asthma
Bønnelykke K et al. “A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.” Nature Genetics 46(1):51-5 (2014)
Allele A
OR 1.26
p 3.0e-14
N 3,684
Large GWAS
multi-ancestry
asthma, chronic rhinosinusitis
Saarentaus EC et al. “131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma.” Nature Communications 16(1):9879 (2025)
Allele G
OR 1.04
p 1.0e-8
N 774,567
Large GWAS
European
About CDHR3
Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all CDHR3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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