rs696880

This is a regulatory region variant variant in the RTN4R gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

blood protein amount

Gudjonsson A et al. “A genome-wide association study of serum proteins reveals shared loci with common diseases.” Nature Communications 13(1):480 (2022)

Allele G

OR 0.24

p 2.0e-36

N 5,365

Large GWAS

European

reticulon-4 receptor measurement

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)

Allele A

OR 0.24

p 7.0e-18

N 2,935

Large GWAS

Greater Middle Eastern (Middle Eastern, North African or Persian)

About RTN4R

This gene encodes the receptor for reticulon 4, oligodendrocyte myelin glycoprotein and myelin-associated glycoprotein. This receptor mediates axonal growth inhibition and may play a role in regulating axonal regeneration and plasticity in the adult central nervous system. [provided by RefSeq, Jul 2008]

View all RTN4R variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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