rs6971499

This is a regulatory region variant variant in the LINC-PINT gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

pancreatic carcinoma

Klein AP et al. “Genome-wide meta-analysis identifies five new susceptibility loci for pancreatic cancer.” Nature Communications 9(1):556 (2018)
Allele T
OR 1.23
p 7.0e-14
N 21,536
Meta-analysisLarge GWAS
European
Wolpin BM et al. “Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.” Nature Genetics 46(9):994-1000 (2014)
Allele T
OR 1.27
p 3.0e-12
N 6,785
Large GWAS
European
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Research that mentions this SNP (1)

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Genome‐wide scan of long noncoding RNA single nucleotide polymorphisms and pancreatic cancer susceptibility
AssociationN=19,862Chiara Corradi et al.(2021)· International Journal of Cancer

Genome-wide scan of long noncoding RNA (lncRNA) variants in 19,862 individuals identified five novel lncSNP associations with pancreatic ductal adenocarcinoma (PDAC) risk. The strongest association was rs7046076 (C allele, OR=1.13, 95% CI=1.09-1.18, P=9.73×10⁻⁹) in the NONHSAG053086.2/lnc-SMC2-1 lncRNA, which disrupts binding to hsa-mir-1256, regulating genes including CDKN2B and DAAM1 involved in cell cycle control and cell migration.

Traits studied:Pancreatic cancerPancreatic ductal adenocarcinoma (PDAC)Pancreatic neuroendocrine tumors
PubMedDOIMetascience Observatory

About LINC-PINT

Involved in negative regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

View all LINC-PINT variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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