rs700753

This is a regulatory region variant variant.

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

IGF-1 measurement, IGFBP-3 measurement

Teumer A et al. “Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.” Aging Cell 15(5):811-24 (2016)
Allele C
OR —
p 7.0e-48
N 18,995
Meta-analysisLarge GWAS
European

IGFBP-3 measurement

Teumer A et al. “Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.” Aging Cell 15(5):811-24 (2016)
Allele C
OR —
p 1.0e-46
N 18,995
Meta-analysisLarge GWAS
European

glomerular filtration rate

Liu H et al. “Epigenomic and transcriptomic analyses define core cell types, genes and targetable mechanisms for kidney disease.” Nature Genetics 54(7):950-962 (2022)
Allele G
OR 14.12
p 3.0e-45
N 1,508,659
Large GWAS
multi-ancestry
Wuttke M et al. “A catalog of genetic loci associated with kidney function from analyses of a million individuals.” Nature Genetics 51(6):957-972 (2019)
Allele G
OR 0.00
p 5.0e-29
N 765,348
Large GWAS
multi-ancestry
Stanzick KJ et al. “Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals.” Nature Communications 12(1):4350 (2021)
Allele G
OR 0.00
p 5.0e-20
N 460,826
Large GWAS
European, NR

IGF-1 measurement

Teumer A et al. “Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.” Aging Cell 15(5):811-24 (2016)
Allele C
OR —
p 2.0e-23
N 27,520
Meta-analysisLarge GWAS
European

basigin measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.04
p 6.0e-16
N 47,745
Large GWAS
European

blood urea nitrogen amount

Stanzick KJ et al. “Discovery and prioritization of variants and genes for kidney function in >1.2 million individuals.” Nature Communications 12(1):4350 (2021)
Allele G
OR 0.00
p 3.0e-15
N 852,680
Large GWAS
European
Wuttke M et al. “A catalog of genetic loci associated with kidney function from analyses of a million individuals.” Nature Genetics 51(6):957-972 (2019)
Allele G
OR 0.00
p 2.0e-10
N 416,178
Large GWAS
European, NR

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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