rs7008482

This case-control study examined the association between West African ancestry (WAA) and prostate cancer (PCa) risk and aggressiveness in 291 Puerto Rican (PR) and 200 African American (AA) cases versus 133 PR and 207 AA controls. The SNP rs7824364 at chromosome 8q24 was significantly associated with PCa in both populations (p<0.0001 for AA, p=0.0001 for PR), with 82% of AA cases and 41% of PR cases carrying 1-2 risk alleles. Among PR men, those with the rs7824364 risk allele showed elevated WAA (39% versus 29%, p=0.034). No direct association between WAA and PCa aggressiveness was found.

A candidate region association study of 10 previously reported 8q24 SNPs in African-Barbadian men from the Prostate Cancer in a Black Population (PCBP) study found one significant association with prostate cancer. Rs2124036 homozygous C/C genotype showed significant association with prostate cancer risk (OR = 2.7, 95% CI 1.3-5.3, P = 0.005). Meta-analysis across three Caribbean populations (Barbados, Jamaica, Tobago) for rs16901979 and rs1447295 identified rs16901979 A allele as significantly associated (Z = 2.73, p = 0.006, OR = 1.31, 95% CI 1.09-1.58).

This study examined 10 chromosome 8q24 SNPs in 1,157 men (308 prostate cancer cases, 469 controls from West Africa, and additional Caribbean and population samples) to determine the prevalence and risk magnitude of 8q24 variants in populations of African descent. The study replicated associations between prostate cancer risk and rs6983561 (OR=0.6, P=0.03), rs16901979 (OR=1.6, P=0.03), and rs7008482 (OR=2.3) in West African men, with no significant heterogeneity of effects across African descent populations.