rs7019241
This is a intron variant variant in the GOLM1 gene.
▶Research that mentions this SNP (1)
▶GAB2 as an Alzheimer Disease Susceptibility GeneAssociationN=4,007Brit-Maren M. Schjeide et al.(2009)· Archives of Neurology
This follow-up study of genomewide association findings tested 4 putative Alzheimer's disease susceptibility loci from prior GWA studies in 4,007 DNA samples from 1,299 families with AD. Only rs7101429 in GAB2 showed significant evidence of association (P = .002), with a protective effect (OR = 0.76, 95% CI 0.62-0.94). The other 3 loci (GOLM1, chromosome 15q, and chromosome 9p) did not show consistent evidence of association across the datasets.
About GOLM1
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes proteins synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this gene has been observed to be upregulated in response to viral infection. Alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Sep 2009]
View all GOLM1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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