rs7023923

This is a intron variant variant in the LOC105376219 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

monocyte measurement

Akbari P et al. “A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.” Nature Communications 14(1):5023 (2023)
Allele C
OR 0.05
p 5.0e-13
N 39,631
Large GWAS
European
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Research that mentions this SNP (1)

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LPAR1andITGA4regulate peripheral blood monocyte counts
AssociationN=5,347Narelle Maugeri et al.(2011)· Human Mutation

A GWAS follow-up study identifies LPAR1 and ITGA4 as causal genes regulating peripheral blood monocyte counts. rs7023923 (chromosome 9q31) significantly associates with increased LPAR1 expression (P = 9.5 × 10⁻⁶) and monocyte counts, while rs6740847 (chromosome 2q31) associates with decreased ITGA4 expression and increased monocyte counts (combined P = 2.7 × 10⁻¹⁰). These two variants jointly account for 1.2% of variation in monocyte numbers.

Traits studied:Monocyte countsPeripheral blood monocyte numbers
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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