rs7034200

This variant is located in the GLIS3 gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

HOMA-B

Dupuis J et al. “New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.” Nature Genetics 42(2):105-116 (2010)
Allele A
OR 0.02
p 1.0e-13
N 36,466
Large GWAS
European

type 2 diabetes mellitus

Vujkovic M et al. “Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.” Nature Genetics 52(7):680-691 (2020)
Allele C
OR 0.06
p 3.0e-12
N 216,287
Meta-analysisLarge GWAS
East Asian, South Asian
Suzuki K et al. “Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.” Nature Genetics 51(3):379-386 (2019)
Allele C
OR 1.06
p 8.0e-12
N 191,764
Large GWAS
East Asian

grip strength measurement

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele C
OR 0.01
p 2.0e-8
N 404,112
Large GWAS
European

blood glucose amount

Lagou V et al. “Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.” Nature Communications 12(1):24 (2021)
Allele A
OR 0.02
p 7.0e-9
N 73,089
Large GWAS
European
Wessel J et al. “Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.” Nature Communications 6:5897 (2015)
Allele A
OR 0.02
p 3.0e-8
N 60,564
Large GWAS
multi-ancestry
Dupuis J et al. “New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.” Nature Genetics 42(2):105-116 (2010)
Allele A
OR 0.02
p 1.0e-12
N 46,186
Large GWAS
European

About GLIS3

This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]

View all GLIS3 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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