rs707176
This variant is located in the GRIA1 gene.
▶ClinVar annotation
▶Research that mentions this SNP (1)
▶Influence of GRIA1, GRIA2 and GRIA4 polymorphisms on diagnosis and response to treatment in patients with major depressive disorderAssociationN=315Alberto Chiesa et al.(2012)· European Archives of Psychiatry and Clinical Neuroscience
A case-control association study of 145 MDD patients and 170 controls found no significant associations between 17 SNPs in GRIA1, GRIA2, and GRIA4 and major depressive disorder diagnosis or antidepressant response. However, a marginal association was observed between rs4302506 C allele (and rs4403097 T allele) in GRIA2 and lower age of onset of MDD (P=0.003 and P=0.005, respectively).
About GRIA1
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
View all GRIA1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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