rs710079

This is a regulatory region variant variant in the MPG gene.

▶

GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele T
OR 0.01
p 1.0e-9
N 5,314,291
Large GWAS
European, Hispanic or Latin American, East Asian, African unspecified, South Asian
▶

Research that mentions this SNP (1)

▶
Genetic polymorphisms of the DNA repair geneMPG may be associated with susceptibility to rheumatoid arthritis
AssociationN=384Chen SY et al.(2010)· Journal of Applied Genetics

A case-control study of 192 Taiwanese RA patients and 192 controls investigated associations between four MPG gene polymorphisms (rs3176364, rs710079, rs2858056, rs2541632) and rheumatoid arthritis susceptibility. Significant differences in genotype distributions were found at rs710079 (P=0.040) and rs2858056 (P=0.029), with the GG genotype at rs2858056 showing increased RA risk. The GCGC haplotype was significantly associated with RA progression (P=0.003, OR=1.75, 95% CI=1.20-1.55).

Traits studied:Rheumatoid arthritis
DOIMetascience Observatory

About MPG

Enables DNA binding activity. Predicted to be involved in base-excision repair. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

View all MPG variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…