rs7115856

This is a regulatory region variant variant in the HSD17B12 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

sleep duration trait

Scammell BH et al. “Multi-ancestry genome-wide analysis identifies shared genetic effects and common genetic variants for self-reported sleep duration.” Human Molecular Genetics 32(18):2797-2807 (2023)

Allele C

OR 0.01

p 7.0e-11

N 483,235

Large GWAS

multi-ancestry

Jansen PR et al. “Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways.” Nature Genetics 51(3):394-403 (2019)

Allele C

OR 0.01

p 1.0e-9

N 384,317

Large GWAS

European

About HSD17B12

This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation. [provided by RefSeq, Oct 2011]

View all HSD17B12 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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