rs7120957
This variant is located in the MADD gene.
▶GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (6)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
esterified cholesterol measurement, high density lipoprotein cholesterol measurement
free cholesterol:total lipids ratio, intermediate density lipoprotein measurement
cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement
low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio
VLDL particle size
fatty acid amount
About MADD
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
View all MADD variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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