rs7132513

This variant is located in the ANKS1B gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

handedness

Cuellar-Partida G et al. “Genome-wide association study identifies 48 common genetic variants associated with handedness.” Nature Human Behaviour 5(1):59-70 (2021)

Allele C

OR 1.03

p 2.0e-11

N 1,766,671

Large GWAS

European

About ANKS1B

This gene encodes a multi-domain protein that is predominantly expressed in brain and testis. This protein interacts with amyloid beta protein precursor (AbetaPP) and may have a role in normal brain development, and in the pathogenesis of Alzheimer's disease. Expression of this gene has been shown to be elevated in patients with pre-B cell acute lymphocytic leukemia associated with t(1;19) translocation. Alternatively spliced transcript variants encoding different isoforms (some with different subcellular localization, PMID:15004329) have been described for this gene. [provided by RefSeq, Aug 2011]

View all ANKS1B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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