rs7148590

This is a regulatory region variant variant in the FNTB gene.

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ClinVar annotation

Benign★☆☆☆
1 submitter
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Research that mentions this SNP (1)

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Polymorphisms of the lamina maturation pathway and their association with the metabolic syndrome: the DESIR prospective study
AssociationN=3,916Benedicte Fontaine-Bisson et al.(2010)· Journal of Molecular Medicine

This prospective cohort study examined 23 tagging SNPs in five genes of the lamin maturation pathway (LMNA, FNTA, FNTB, ZMPSTE24, ICMT) in 3,916 French participants from the DESIR study for associations with metabolic syndrome. Single locus and haplotype analyses found no significant associations with metabolic syndrome risk after multiple testing correction. Two suggestive interactions were detected (P<0.002): LMNA rs4641 with FNTA rs10958736 (OR=1.68 for T allele carriers in A allele background) and LMNA rs4641 with FNTB rs11622366 in smokers (OR=2.14), but these did not remain significant after correction. The authors concluded that common polymorphisms in lamin pathway genes are unlikely to strongly influence metabolic syndrome risk in European populations.

Traits studied:Metabolic syndromeType 2 diabetes
PubMedDOIMetascience Observatory

About FNTB

Enables acetyltransferase activator activity; enzyme binding activity; and zinc ion binding activity. Contributes to protein farnesyltransferase activity. Involved in protein farnesylation and regulation of microtubule-based movement. Part of microtubule associated complex and protein farnesyltransferase complex. Implicated in anxiety disorder. [provided by Alliance of Genome Resources, Jul 2025]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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