rs715948
This is a regulatory region variant variant in the LRP1 gene.
▶Research that mentions this SNP (1)
▶Low‐density lipoprotein receptor‐related protein 1 variant interacts with saturated fatty acids in puerto ricansAssociationN=920Caren E. Smith et al.(2013)· Obesity
In a Puerto Rican cohort (n=920), the LRP1 rs1799986 T allele showed significant gene-diet interactions with saturated fat intake for obesity-related traits. High saturated fat intake was associated with higher BMI (p=0.001), waist circumference (p=0.008), and hip circumference (p=0.003) in T allele carriers, with strongest interactions for palmitic acid (C16:0; p=0.0007) and stearic acid (C18:0; p=0.005).
About LRP1
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
View all LRP1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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