rs7162542

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Wood AR et al. “Defining the role of common variation in the genomic and biological architecture of adult human height.” Nature Genetics 46(11):1173-86 (2014)

Allele C

OR 0.05

p 8.0e-55

N 253,288

Large GWAS

European

chronic obstructive pulmonary disease

Cosentino J et al. “Inference of chronic obstructive pulmonary disease with deep learning on raw spirograms identifies new genetic loci and improves risk models.” Nature Genetics 55(5):787-795 (2023)

Allele C

OR 0.03

p 4.0e-54

N 325,027

Large GWAS

European

forced expiratory volume

Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)

Allele C

OR 0.03

p 3.0e-49

N 373,397

Large GWAS

European

BMI-adjusted waist circumference

Christakoudi S et al. “GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.” Scientific Reports 11(1):10688 (2021)

Allele C

OR 0.04

p 3.0e-44

N 186,825

Major Consortium StudyLarge GWAS

European

Justice AE et al. “Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.” Nature Communications 8:14977 (2017)

Allele C

OR 0.05

p 2.0e-16

N 152,914

Meta-analysisLarge GWAS

multi-ancestry

Shungin D et al. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518(7538):187-196 (2015)

Allele C

OR 0.04

p 3.0e-16

N 143,480

Large GWAS

multi-ancestry

Graff M et al. “Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.” Plos Genetics 13(4):e1006528 (2017)

Allele C

OR 0.04

p 2.0e-14

N 122,328

Meta-analysisLarge GWAS

multi-ancestry

BMI-adjusted hip circumference

Allele C

OR 0.04

p 1.0e-30

N 186,825

Major Consortium StudyLarge GWAS

European

Shungin D et al. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518(7538):187-196 (2015)

Allele C

OR 0.04

p 1.0e-20

N 143,480

Large GWAS

multi-ancestry

comparative body size at age 10, self-reported

Richardson TG et al. “Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study.” Bmj (clinical Research Ed.) 369:m1203 (2020)

Allele C

OR 0.01

p 4.0e-11

N 453,169

Large GWAS

European

BMI-adjusted waist-hip ratio

Allele C

OR 0.02

p 2.0e-10

N 186,825

Major Consortium StudyLarge GWAS

European

body mass index

Hawkes G et al. “Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood.” Diabetologia 66(8):1472-1480 (2023)

Allele C

OR 0.01

p 1.0e-8

N 441,761

Large GWAS

European

smoking behavior, BMI-adjusted waist circumference

Justice AE et al. “Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.” Nature Communications 8:14977 (2017)

Allele C

OR 0.03

p 2.0e-12

N 195,506

Meta-analysisLarge GWAS

multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

rs7162542

GWAS Catalog Trait Associations (9)

body height

chronic obstructive pulmonary disease

forced expiratory volume

BMI-adjusted waist circumference

BMI-adjusted hip circumference

comparative body size at age 10, self-reported

BMI-adjusted waist-hip ratio

body mass index

smoking behavior, BMI-adjusted waist circumference

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