rs7164503
This is a intron variant variant in the ANP32A gene.
▶Research that mentions this SNP (1)
▶Variation at the ANP32A gene is associated with risk of hip osteoarthritis in womenAssociationN=5,019Ana M. Valdes et al.(2009)· Arthritis & Rheumatism
Genetic variation at the ANP32A gene, particularly the rs7164503 intronic SNP, is significantly associated with reduced risk of hip osteoarthritis in women across four cohorts (Mantel-Haenszel OR 0.67, 95% CI 0.53-0.84, P < 3.8 × 10⁻⁴). A similar protective trend was observed for knee OA (OR 0.87, P < 0.055). ANP32A encodes a tumor suppressor involved in apoptosis and Wnt signaling pathways.
About ANP32A
Enables RNA binding activity. Involved in nucleocytoplasmic transport. Located in endoplasmic reticulum; nucleus; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
View all ANP32A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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