rs7166081

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GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body fat percentage

Martin S et al. “Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease.” Diabetes 70(8):1843-1856 (2021)
Allele A
OR —
β 0.016
p 2.0e-20
N 442,278
Large GWAS
European

waist-hip ratio

Pulit SL et al. “Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.” Human Molecular Genetics 28(1):166-174 (2019)
Allele A
OR 0.02
p 2.0e-16
N 316,772
Meta-analysisLarge GWAS
European

fat pad mass

Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)
Allele A
OR 0.02
p 7.0e-11
N 337,196
Large GWAS
European

eosinophil count

Vuckovic D et al. “The Polygenic and Monogenic Basis of Blood Traits and Diseases.” Cell 182(5):1214-1231.e11 (2020)
Allele A
OR 0.02
p 7.0e-10
N 408,112
Large GWAS
European

BMI-adjusted waist circumference

Shungin D et al. “New genetic loci link adipose and insulin biology to body fat distribution.” Nature 518(7538):187-196 (2015)
Allele A
OR 0.02
p 2.0e-9
N 143,480
Large GWAS
multi-ancestry

forced expiratory volume, 25-hydroxyvitamin D3 measurement

Seo J et al. “Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.” The American Journal of Clinical Nutrition 119(5):1227-1237 (2024)
Allele G
OR —
p 8.0e-9
N 115,312
Meta-analysisLarge GWAS
multi-ancestry

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele G
OR 0.01
p 1.0e-8
N 472,730
Large GWAS
East Asian

smoking behavior, BMI-adjusted waist circumference

Justice AE et al. “Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.” Nature Communications 8:14977 (2017)
Allele A
OR —
p 8.0e-10
N 195,506
Meta-analysisLarge GWAS
multi-ancestry
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Research that mentions this SNP (1)

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Genome-wide association analysis with selective genotyping identifies candidate loci for adult height at 8q21.13 and 15q22.33-q23 in Mongolians
AssociationN=1,555Tetsuaki Kimura et al.(2008)· Human Genetics

Genome-wide association study in 1,555 Khalkh-Mongolian individuals identified two candidate loci for adult height using selective genotyping and microsatellite/SNP analysis. SNP rs2220456 at 8q21.13 showed the strongest association (P = 0.000016), while SNP rs8038652 in IQCH intron 1 at 15q22.33 was highly significant (P = 0.0003 overall, P = 0.000046 for AA genotype under recessive model, OR = 0.59). The study also identified additional significant SNPs in SMAD3 and FLJ11506 genes in the same region.

Traits studied:Adult height
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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