rs7178572
This variant is located in the HMG20A gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
blood glucose amount
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele A
OR 0.02
p 3.0e-52
N 928,679
Large GWAS
multi-ancestry
Lagou V et al. “Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.” Nature Communications 12(1):24 (2021)
Allele A
OR 0.01
p 3.0e-8
N 140,595
Large GWAS
European
type 2 diabetes mellitus
Elashi AA et al. “Genome-wide association study and trans-ethnic meta-analysis identify novel susceptibility loci for type 2 diabetes mellitus.” Bmc Medical Genomics 17(1):115 (2024)
Allele G
OR 0.08
p 4.0e-51
N 6,710,881
Meta-analysisLarge GWAS
multi-ancestry
Zhao W et al. “Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.” Nature Genetics 49(10):1450-1457 (2017)
Allele G
OR 0.06
p 2.0e-8
N 183,651
Large GWAS
multi-ancestry
Mahajan A et al. “Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.” Nature Genetics 46(3):234-44 (2014)
Allele G
OR 1.08
p 2.0e-11
N 110,452
Meta-analysisLarge GWAS
multi-ancestry
Perry JR et al. “Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.” Plos Genetics 8(5):e1002741 (2012)
Allele G
OR 1.11
p 1.0e-8
N 60,651
Large GWAS
Kooner JS et al. “Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.” Nature Genetics 43(10):984-9 (2011)
Allele G
OR 1.09
p 7.0e-11
N 20,019
Large GWAS
South Asian
glucose measurement
Chen J et al. “The trans-ancestral genomic architecture of glycemic traits.” Nature Genetics 53(6):840-860 (2021)
Allele A
OR —
β 0.012
p 7.0e-10
N 200,622
Large GWAS
European
About HMG20A
Enables identical protein binding activity. Predicted to be involved in regulation of gene expression. Predicted to act upstream of or within negative regulation of neuron differentiation; negative regulation of protein sumoylation; and negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
View all HMG20A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…