rs7203459
This is a regulatory region variant variant in the CLEC16A gene.
▶GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (4)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
eosinophil percentage of leukocytes
Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele C
OR 0.05
p 6.0e-34
N 172,378
Large GWAS
European
eosinophil percentage of granulocytes
Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele C
OR 0.05
p 7.0e-33
N 170,536
Large GWAS
European
neutrophil percentage of granulocytes
Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele C
OR 0.05
p 5.0e-31
N 170,672
Large GWAS
European
asthma
Shrine N et al. “Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study.” The Lancet. Respiratory Medicine 7(1):20-34 (2019)
Allele T
OR 1.16
p 4.0e-18
N 30,810
Large GWAS
European
About CLEC16A
This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
View all CLEC16A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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