rs7248003
▶GWAS Catalog Trait Associations (11)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (11)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
eicosenoyl sphingomyelin measurement
Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)
Allele T
OR 0.21
p 3.0e-35
N 7,900
Large GWAS
multi-ancestry
level of sphingomyelin d18:1/18:1 in blood
Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)
Allele T
OR 0.15
p 2.0e-24
N 10,182
Large GWAS
multi-ancestry
sphingomyelin (d18:1/19:0, d19:1/18:0) measurement
Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)
Allele T
OR 0.18
p 8.0e-22
N 6,171
Large GWAS
multi-ancestry
level of N-stearoylsphingosine-1-phosphocholine in blood
Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)
Allele T
OR 0.14
p 1.0e-21
N 11,209
Large GWAS
multi-ancestry
blood metabolite level
Feofanova EV et al. “Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.” Nature Communications 14(1):3111 (2023)
Allele T
OR 0.13
p 4.0e-14
N 7,435
Large GWAS
multi-ancestry
serum metabolite level
Feofanova EV et al. “A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos.” American Journal of Human Genetics 107(5):849-863 (2020)
Allele C
OR 0.18
p 6.0e-13
N 3,926
Large GWAS
Hispanic or Latin American
N-stearoyl-sphingadienine (d18:2/18:0) measurement
Schlosser P et al. “Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.” Nature Genetics 55(6):995-1008 (2023)
Allele T
OR 0.14
p 9.0e-13
N 3,644
Large GWAS
European
GM3 ganglioside measurement
Cadby G et al. “Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.” Nature Communications 13(1):3124 (2022)
Allele T
OR 0.17
p 7.0e-11
N 4,492
Large GWAS
European
Sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0) measurement
Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)
Allele T
OR 0.07
p 6.0e-10
N 14,296
Large GWAS
European
level of ceramide
Cadby G et al. “Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease.” Nature Communications 13(1):3124 (2022)
Allele T
OR 0.20
p 5.0e-16
N 4,492
Large GWAS
European
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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