rs72525532
This variant is located in the ZPR1 gene.
▶Research that mentions this SNP (1)
▶Single nucleotide polymorphism associated with nonsyndromic cleft palate influences the processing of miR‐140AssociationN=116Ling Li et al.(2010)· American Journal of Medical Genetics Part A
This case-control study of 57 children/adolescents with metabolic syndrome (MetS) and 59 controls examined five SNPs in the APOA5 gene's miRNA target sites. Only rs72525532 (c.*285_*286insGA) showed variation, with the AA insertion genotype significantly more frequent in MetS cases (12.28%) versus controls (1.7%, P=0.012) and associated with increased triglycerides and MetS risk (OR=8.12, P=0.05), though this association became non-significant after age adjustment (OR=5.66, P=0.124).
About ZPR1
The protein encoded by this gene is found in the cytoplasm of quiescent cells but translocates to the nucleolus in proliferating cells. The encoded protein interacts with survival motor neuron protein (SMN1) to enhance pre-mRNA splicing and to induce neuronal differentiation and axonal growth. Defects in this gene or the SMN1 gene can cause spinal muscular atrophy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
View all ZPR1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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