rs7255066

This is a upstream gene variant variant in the PVR gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

blood protein amount

Hillary RF et al. “Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936.” Nature Communications 10(1):3160 (2019)
Allele C
OR 0.66
p 2.0e-29
N 750
Small GWAS
European

basal cell adhesion molecule amount

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.04
p 3.0e-12
N 47,745
Large GWAS
European

Alzheimer's disease biomarker measurement

Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)
Allele C
OR 0.01
p 1.0e-8
N 568,836
Large GWAS
European

About PVR

The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

View all PVR variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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