rs725613
This is a upstream gene variant variant in the CLEC16A gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
eosinophil count
Chen MH et al. “Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations.” Cell 182(5):1198-1213.e14 (2020)
Allele G
OR —
p 4.0e-120
N 583,850
Large GWAS
multi-ancestry
sclerosing cholangitis
Ji SG et al. “Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.” Nature Genetics 49(2):269-273 (2017)
Allele T
OR 1.20
p 4.0e-13
N 14,890
Large GWAS
European
Han Y et al. “Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis.” Nature Communications 14(1):1069 (2023)
Allele T
OR 0.08
p 4.0e-13
N 14,890
Large GWAS
European
level of bone marrow proteoglycan in blood
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele G
OR 0.04
p 1.0e-12
N 47,745
Large GWAS
European
About CLEC16A
This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
View all CLEC16A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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