rs72805613

This variant is located in the FTO gene.

▶

GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

neutrophil count

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.02

p 9.0e-14

N 261,847

Major Consortium StudyLarge GWAS

European

atrial fibrillation

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)

Allele A

OR 0.05

p 1.0e-11

N 622,233

Major Consortium StudyLarge GWAS

multi-ancestry

sexual activity behaviour attribute

Karlsson Linnér R et al. “Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.” Nature Genetics 51(2):245-257 (2019)

Allele A

OR 0.01

p 3.0e-9

N 370,711

Large GWAS

European

diet measurement, body mass index

D'Urso S et al. “New Insights into Polygenic Score-Lifestyle Interactions for Cardiometabolic Risk Factors from Genome-Wide Interaction Analyses.” Nutrients 15(22) (2023)

Allele G

OR 0.04

p 2.0e-8

N 382,375

Large GWAS

European

About FTO

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

rs72805613

GWAS Catalog Trait Associations (4)

neutrophil count

atrial fibrillation

sexual activity behaviour attribute

diet measurement, body mass index

About FTO

Community Wiki

Comments