rs7291042

This is a intron variant variant in the SGSM1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

level of glutathione hydrolase 1 proenzyme in blood

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele T

OR 0.05

p 7.0e-19

N 47,745

Large GWAS

European

type 2 diabetes mellitus

Suzuki K et al. “Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.” Nature 627(8003):347-357 (2024)

Allele T

OR —

p 3.0e-9

N 2,535,601

Large GWAS

multi-ancestry

About SGSM1

Enables GTPase activator activity and small GTPase binding activity. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasmic vesicle membrane and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

View all SGSM1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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