rs72932557

This is a protein-altering variant in the CARF gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

white matter hyperintensity measurement

Jian X et al. “Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.” Stroke 49(8):1812-1819 (2018)

Allele T

OR —

p 4.0e-8

N 3,726

Large GWAS

multi-ancestry

About CARF

Enables DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in cellular response to calcium ion. Predicted to be located in granular component. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

View all CARF variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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