rs73078357

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hepatocyte growth factor-like protein level

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele C
OR 0.85
p 5.0e-120
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)

thioredoxin domain-containing protein 12 measurement

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele C
OR 0.67
p 4.0e-73
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)

sodium measurement

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.03
p 3.0e-14
N 421,240
Major Consortium StudyLarge GWAS
European

body mass index

Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)
Allele C
OR 0.03
p 2.0e-12
N 342,566
Large GWAS
European

tumor necrosis factor ligand superfamily member 6 isoform FasL soluble form amount

Thareja G et al. “Differences and commonalities in the genetic architecture of protein quantitative trait loci in European and Arab populations.” Human Molecular Genetics 32(6):907-916 (2023)
Allele C
OR 0.25
p 7.0e-12
N 2,935
Large GWAS
Greater Middle Eastern (Middle Eastern, North African or Persian)

BMI-adjusted waist circumference

Christakoudi S et al. “GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.” Scientific Reports 11(1):10688 (2021)
Allele C
OR 0.03
p 1.0e-11
N 186,825
Major Consortium StudyLarge GWAS
European

health study participation

Tyrrell J et al. “Genetic predictors of participation in optional components of UK Biobank.” Nature Communications 12(1):886 (2021)
Allele T
OR 1.01
p 2.0e-9
N 451,097
Major Consortium StudyLarge GWAS
European
Adams MJ et al. “Factors associated with sharing e-mail information and mental health survey participation in large population cohorts.” International Journal of Epidemiology 49(2):410-421 (2020)
Allele T
OR 0.01
p 4.0e-8
N 371,417
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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