rs73114872

This is a downstream gene variant variant in the SPRYD4 gene.

▶

GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

tyrosine measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.07

p 2.0e-135

N 450,015

Large GWAS

multi-ancestry

histidine measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele C

OR 0.06

p 2.0e-103

N 450,015

Large GWAS

multi-ancestry

glutamine measurement

Li-Gao R et al. “Genetic Studies of Metabolomics Change After a Liquid Meal Illuminate Novel Pathways for Glucose and Lipid Metabolism.” Diabetes 70(12):2932-2946 (2021)

Allele C

OR 0.26

p 3.0e-22

Large GWAS

blood urea nitrogen amount

Wuttke M et al. “A catalog of genetic loci associated with kidney function from analyses of a million individuals.” Nature Genetics 51(6):957-972 (2019)

Allele T

OR 0.01

p 1.0e-15

N 416,178

Large GWAS

European, NR

2-aminobutyrate measurement

Surendran P et al. “Rare and common genetic determinants of metabolic individuality and their effects on human health.” Nature Medicine 28(11):2321-2332 (2022)

Allele T

OR 0.10

p 8.0e-15

N 14,296

Large GWAS

European

fibroblast growth factor 21 level

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.05

p 1.0e-12

N 47,745

Large GWAS

European

About SPRYD4

Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

View all SPRYD4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Loading comments…