rs7315280

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GWAS Catalog Trait Associations (8)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hippocampal CA4 volume

Liu N et al. “Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.” Nature Genetics 55(7):1126-1137 (2023)
Allele G
OR 0.12
p 5.0e-25
N 38,977
Large GWAS
European, East Asian

dentate gyrus volume

Liu N et al. “Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.” Nature Genetics 55(7):1126-1137 (2023)
Allele G
OR 0.11
p 1.0e-21
N 38,977
Large GWAS
European, East Asian

subiculum volume

Liu N et al. “Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.” Nature Genetics 55(7):1126-1137 (2023)
Allele G
OR 0.09
p 3.0e-16
N 38,977
Large GWAS
European, East Asian

hippocampus molecular layer volume

Liu N et al. “Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.” Nature Genetics 55(7):1126-1137 (2023)
Allele G
OR 0.08
p 6.0e-13
N 38,977
Large GWAS
European, East Asian

amygdala volume

Ji Y et al. “Cross-ancestry and sex-stratified genome-wide association analyses of amygdala and subnucleus volumes.” Nature Genetics 57(4):839-850 (2025)
Allele G
OR 0.08
p 6.0e-18
N 42,397
Large GWAS
multi-ancestry

brain volume

Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele G
OR 0.11
p 9.0e-14
N 21,282
Major Consortium StudyLarge GWAS
European

hippocampal CA3 volume

Liu N et al. “Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.” Nature Genetics 55(7):1126-1137 (2023)
Allele G
OR 0.09
p 4.0e-14
N 38,977
Large GWAS
European, East Asian

hippocampal volume

Liu N et al. “Cross-ancestry genome-wide association meta-analyses of hippocampal and subfield volumes.” Nature Genetics 55(7):1126-1137 (2023)
Allele G
OR 0.11
p 4.0e-21
N 38,977
Large GWAS
European, East Asian

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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