rs73294447
This variant is located in the SYNDIG1L gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
open-angle glaucoma
Han X et al. “Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.” Nature Genetics 55(7):1116-1125 (2023)
Allele T
OR 0.25
p 2.0e-12
N 432,017
Large GWAS
multi-ancestry
intraocular pressure measurement
Craig JE et al. “Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression.” Nature Genetics 52(2):160-166 (2020)
Allele T
OR —
p 3.0e-8
N 133,492
Large GWAS
European
About SYNDIG1L
Predicted to be located in Golgi apparatus. Predicted to be active in intracellular membrane-bounded organelle and membrane. [provided by Alliance of Genome Resources, Apr 2025]
View all SYNDIG1L variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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