rs733457
This variant is located in the GRM4 gene.
▶Research that mentions this SNP (1)
▶Neurotransmission and bipolar disorder: A systematic family‐based association studyAssociationN=1,115Jiajun Shi et al.(2008)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
A family-based association study examined 1005 tag SNPs across 90 genes from five neurotransmission systems (dopaminergic, serotonergic, noradrenergic, GABAergic, and glutamatergic) in 304 bipolar disorder families. Gene-wide significant associations were found for GRIA1 (rs2926835), GRIN2D (rs1799281), and QDPR (rs744731) for allelic associations, and GRIN2C, QDPR, and SLC6A3 for haplotypic associations; however, none survived correction for multiple testing across all systems. The study found no significant SNP associations with comorbid sub-phenotypes or gene-gene interactions, suggesting common variants in these neurotransmission genes do not have major effects on bipolar disorder risk.
About GRM4
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
View all GRM4 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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