rs73495427

This is a regulatory region variant variant in the CERS4 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

metabolite measurement

Tahir UA et al. “Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.” Nature Communications 13(1):4923 (2022)

Allele T

OR 0.27

p 3.0e-12

N 2,466

Large GWAS

multi-ancestry

About CERS4

Enables sphingosine N-acyltransferase activity. Involved in ceramide biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all CERS4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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