rs738499
This variant is located in the TEF gene.
▶Research that mentions this SNP (1)
▶Association of Tef polymorphism with depression in Parkinson diseaseAssociationN=408Ping Hua et al.(2012)· Movement Disorders
This study examined the association between circadian gene polymorphisms and depression severity in 408 Parkinson's disease patients. The Tef rs738499 polymorphism was significantly associated with higher Hamilton Depression Rating Scale (HAMD) scores (P = 0.004), explaining 1.8% of variance in depression symptoms after adjusting for clinical variables. Cry1 rs2287161 and Cry2 rs10838524 showed no significant associations with depression in this PD cohort.
About TEF
This gene encodes a member of the PAR (proline and acidic amino acid-rich) subfamily of basic region/leucine zipper (bZIP) transcription factors. It is expressed in a broad range of cells and tissues in adult animals, however, during embryonic development, TEF expression appears to be restricted to the developing anterior pituitary gland, coincident with the appearance of thyroid-stimulating hormone, beta (TSHB). Indeed, TEF can bind to, and transactivate the TSHB promoter. It shows homology (in the functional domains) with other members of the PAR-bZIP subfamily of transcription factors, which include albumin D box-binding protein (DBP), human hepatic leukemia factor (HLF) and chicken vitellogenin gene-binding protein (VBP); VBP is considered the chicken homologue of TEF. Different members of the subfamily can readily form heterodimers, and share DNA-binding, and transcriptional regulatory properties. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
View all TEF variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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