rs74049259
This is a intron variant variant in the PLCH2 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
microbiome measurement
Fang ZY et al. “Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization.” Cell Host & Microbe 32(10):1838-1852.e5 (2024)
Allele T
OR 0.90
p 9.0e-9
N 733
Small GWAS
European, South Asian, East Asian, African American or Afro-Caribbean, Other admixed ancestry, Other
About PLCH2
PLCH2 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave PtdIns(4,5) P2 to generate second messengers inositol 1,4,5-trisphosphate and diacylglycerol (Zhou et al., 2005 [PubMed 16107206]).[supplied by OMIM, Jun 2009]
View all PLCH2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…