rs7434630

This variant is located in the ADRA2C gene.

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ClinVar annotation

Benign
1 submitter

ADRA2C-related disorder

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Research that mentions this SNP (1)

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The correlation between SNPs within the gene of adrenergic receptor and neuropeptide Y and risk of cervical vertigo
AssociationN=420Jianlong Han et al.(2018)· Journal of Clinical Laboratory Analysis

Case-control study of 216 cervical vertigo patients and 204 controls identifying SNPs in ADRA1A, ADRB1, ADRB2, and NPY genes significantly associated with cervical vertigo risk (ORs 0.62-2.07) and clinical prognosis markers (JOA score and recovery rate). ADRA1A rs3802241 showed OR=2.07 for disease risk and protective effect on prognosis; NPY variants predicted recovery outcomes.

Traits studied:Cervical vertigoInferior cervical vertigoSuperior cervical vertigoVertebral artery blood flow
PubMedDOIMetascience Observatory

About ADRA2C

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The mouse studies revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes the alpha2C subtype, which contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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