rs7439366

A two-stage case-control study in Chinese women examined associations between SNPs in sex hormone regulation genes and never-smoking lung cancer risk. SNP rs12233719 (G>T) in UGT2B7 was associated with increased NSCLC risk, with adjusted OR = 1.58 (95% CI: 1.15-2.16) in the training set and 1.49 (95% CI: 1.02-2.18) in the validation set; combined OR = 1.54 (95% CI: 1.21-1.96). UGT2B7 was upregulated in tumor tissues and associated with poor prognosis.

This case-control study of over 1,800 Caucasian subjects examined genetic variation in UGT1A and UGT2B genes for colorectal cancer (CRC) risk. UGT1A haplotypes were significantly associated with CRC risk: the T-G haplotype in UGT1A10 (rs17864678, rs10929251) decreased proximal and distal colon cancer risk (OR = 0.28-0.32), while the C-T-G haplotype in the UGT1A shared exons (rs7578153, rs10203853, rs6728940) increased CRC risk in males (OR = 2.56). In UGT2B15, a haplotype containing the functional variant rs4148269 (K523T, c.C1568A) and rs6837575 increased rectal cancer risk (OR = 2.57 overall, OR = 3.08 in females). An interaction between high NSAID use and the UGT1A A-G-T haplotype (rs6717546, rs1500482, rs7586006) decreased CRC risk.