rs74652506
This is a intron variant variant in the ANO10 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
gastroesophageal reflux disease
An J et al. “Gastroesophageal reflux GWAS identifies risk loci that also associate with subsequent severe esophageal diseases.” Nature Communications 10(1):4219 (2019)
Allele T
OR 1.05
p 3.0e-8
N 385,276
Large GWAS
European, NR
About ANO10
The transmembrane protein encoded by this gene belongs to the anoctamin family of calcium-activated chloride channels, also known as the transmembrane 16 family. The encoded protein contains eight transmembrane domains with cytosolic N- and C-termini. Defects in this gene may cause autosomal recessive spinocerebellar ataxia-10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
View all ANO10 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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