rs74688172
This is a intron variant variant in the PRR5L gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
psoriasis
Dand N et al. “GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.” Nature Communications 16(1):2051 (2025)
Allele A
OR 1.25
p 6.0e-20
N 494,544
Meta-analysisLarge GWAS
European
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele A
OR 0.21
p 3.0e-11
N 631,638
Major Consortium StudyLarge GWAS
multi-ancestry
About PRR5L
Enables ubiquitin protein ligase binding activity. Involved in several processes, including TORC2 signaling; regulation of fibroblast migration; and regulation of primary metabolic process. Part of TORC2 complex. [provided by Alliance of Genome Resources, Jul 2025]
View all PRR5L variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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