rs748708

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

CD6 measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.07
p 1.0e-25
N 47,745
Large GWAS
European
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Research that mentions this SNP (1)

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Contribution of TMC6 and TMC8 (EVER1 and EVER2) variants to cervical cancer susceptibility
AssociationN=5,270Felipe A. Castro et al.(2012)· International Journal of Cancer

This candidate gene study evaluated 22 SNPs in the TMC6/8 (EVER1/2) genes in 2,989 Swedish cervical cancer cases (CIN III/ICC) and 2,281 controls. Two SNPs showed significant association with cervical cancer susceptibility: rs2290907 (OR=0.6, 95% CI: 0.3-0.9, p=0.02) in TNRC6C and rs16970849 (OR=0.8, 95% CI: 0.66-0.98, p=0.03) in TMC8, supporting the role of the TMC6/8 region in cervical cancer risk.

Traits studied:Cervical cancerCervical intraepithelial neoplasia grade IIIInvasive cervical carcinoma
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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