rs74896528
This variant is located in the SESN2 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
uric acid measurement
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.05
p 9.0e-11
N 129,405
Large GWAS
East Asian
Nakatochi M et al. “Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals.” Communications Biology 2:115 (2019)
Allele T
OR 0.06
p 8.0e-9
N 121,745
Meta-analysisLarge GWAS
multi-ancestry
urate measurement
Tin A et al. “Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.” Nature Genetics 51(10):1459-1474 (2019)
Allele T
OR 0.09
p 1.0e-9
N 457,690
Large GWAS
multi-ancestry
Cho C et al. “Large-scale cross-ancestry genome-wide meta-analysis of serum urate.” Nature Communications 15(1):3441 (2024)
Allele T
OR 0.06
p 1.0e-8
N 219,768
Meta-analysisLarge GWAS
East Asian
▶ClinVar annotation
Benign★☆☆☆
1 submitter1 publicationAbout SESN2
This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions. [provided by RefSeq, Jul 2008]
View all SESN2 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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